EPIDEMIC
Disease: Unknown cause. The latest research suggests epidemic(s) of leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D.
Estimated Death Toll: 30–90% of the population
Location: Southern New England, especially the Wampanoag people
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Cocoliztli Epidemic of 1576