EPIDEMIC Disease: Unknown, Possibly Smallpox Estimated Death Toll: 5 – 10 Million Location: Roman Empire The Antonine Plague of 165 to 180..Read More

PANDEMIC Disease: Black Death Estimated Death Toll: 20–200 million; 20–60% of the European population Location: Europe, Asia, and North Africa The Black Death, also..Read More

EPIDEMIC Disease: Plague Estimated Death Toll: > 20,100 in London Location: London In 1563 London experienced its worst episode of plague during the..Read More

EPIDEMIC Disease: Unknown cause. The latest research suggests epidemic(s) of leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D. Estimated..Read More

EPIDEMIC Disease: Plague Estimated Death Toll: 100,000 Location: England The Great Plague, lasting from 1665 to 1666, was the last major epidemic of..Read More

EPIDEMIC Disease: Plague Estimated Death Toll: 76,000 Location: Austria The Great Plague of Vienna occurred in 1679 in Vienna, Austria, the imperial residence of the..Read More

EPIDEMIC Disease: Plague Estimated Death Toll: 100,000 Location: France The Great Plague of Marseille was the last of the significant European outbreaks of bubonic..Read More

EPIDEMIC Disease: Plague Estimated Death Toll: > 50,000 Location: Russia The Russian plague epidemic of 1770–1772, also known as the Plague of 1771, was..Read More

EPIDEMIC Disease: Yellow Fever Estimated Death Toll: > 50,000 Location: United States During the 1793 yellow fever epidemic in Philadelphia, 5,000 or more people were listed..Read More

PANDEMIC Disease: Cholera Estimated Death Toll: > 100,000 Location: Asia, Europe, North America The second cholera pandemic (1826–1837), also known as the Asiatic cholera pandemic, was a..Read More

PANDEMIC Disease: Cholera Estimated Death Toll: > 1,000,000 Location: Asia, Europe, Africa, North America The third cholera pandemic (1846–60) was the third major outbreak of..Read More

PANDEMIC Disease: Cholera Estimated Death Toll: > 600,000 Location: Middle East The fourth cholera pandemic of the 19th century began in the Ganges Delta..Read More

PANDEMIC Disease: Cholera Estimated Death Toll: > 800,000 Location: Middle East, North Africa, Eastern Europe, and Russia The sixth cholera pandemic (1899–1923) was a..Read More

PANDEMIC Disease: Influenza Estimated Death Toll: up to 100,000,000 Location: Worldwide The 1918 influenza pandemic was an unusually deadly influenza pandemic, the first of the..Read More

PANDEMIC Disease: Influenza Estimated Death Toll: 1,000,000 Location: Worldwide The 1968 flu pandemic was a category 2 flu pandemic whose outbreak in 1968 and 1969..Read More

EPIDEMIC Disease: SARS (SARS-CoV-1) Estimated Death Toll: > 810 Location: Worldwide (29 territories) The 2002–2004 SARS outbreak was an epidemic involving severe acute respiratory..Read More

PANDEMIC Disease: Influenza Estimated Death Toll: 203,000 Location: Worldwide The 2009 flu pandemic or swine flu was an influenza pandemic that lasted from early 2009 to late 2010, and..Read More

PANDEMIC Disease: Middle East Respiratory Syndrome (MERS) Estimated Death Toll: > 862 (as of 13 January 2020) Location: Worldwide Since 2012, an outbreak of Middle..Read More

EPIDEMIC Disease: Zika Virus Epidemic Estimated Death Toll: 53 Location: Worldwide In early 2015, a widespread epidemic of Zika fever, caused by the Zika..Read More